Abstract
Fibroblast growth factor-23 (FGF-23) regulates phosphate metabolism and elevated levels occur in patients with kidney disease and are associated with smortality in maintenance hemodialysis (MHD) patients. Residual renal function (RRF) presumably improves phosphate metabolism in MHD patients. We investigated the role of circulating FGF-23 on urinary phosphate excretion and phosphate balance in 134 MHD patients. Demographics, laboratory data, and excretion capacity of phosphate were recorded. We used multivariable regression to analyze the relationship of serum phosphate with other factors and of the tubular reabsorption rate of phosphate with other factors. Patients with high urinary output (>200 mL/day) had lower serum phosphate, calcium, iPTH, and FGF-23 than patients with low urinary output (
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