Abstract
BackgroundAlterations in ceruloplasmin are currently assumed as one of the mechanisms underlying the development of a number of neurodegenerative disorders. Several studies indicate that elevated serum ceruloplasmin levels may play a role in schizophrenia by exacerbating or perpetuating dopaminergic dysregulation. No study investigating the relationship between ceruloplasmin and obsessive-compulsive disorder (OCD) has been published to date. Nowadays OCD is increasingly speculated to be a different disorder than other anxiety disorders, and rather is considered to be more similar to psychotic disorders. The objective of this study to explore whether there is an association of ceruloplasmin with OCD as in schizophrenia.Method26 pure OCD and 9 co-morbid OCD patients from Gaziantep University Sahinbey Research Hospital, Psychiatry Clinics, diagnosed according to the DSM IV and 40 healthy controls were included in the study. Blood samples were collected; ceruloplasmin levels were measured.ResultsThe mean ceruloplasmin level in pure OCD patients, co-morbid OCD patients, and control group persons were 544.46 ± 26.53, 424.43 ± 31.50 and 222.35 ± 8.88 U/L respectively. Results of all 3 groups differ significantly. Positive predictive value of ceruloplasmin for that cut-off point is 31/31 (100%) and negative predictive value is 40/44 (91%) in our group.ConclusionAlthough the nature of relationship is not clear there was an association between ceruloplasmin levels and OCD in our study.
Highlights
Alterations in ceruloplasmin are currently assumed as one of the mechanisms underlying the development of a number of neurodegenerative disorders
Conclusion: the nature of relationship is not clear there was an association between ceruloplasmin levels and obsessive-compulsive disorder (OCD) in our study
In pure OCD group mean ceruloplasmin level was significantly higher than co-morbid OCD group (p < 0.01)
Summary
Alterations in ceruloplasmin are currently assumed as one of the mechanisms underlying the development of a number of neurodegenerative disorders. Ceruloplasmin is a protein of the α2-globulin fraction of human blood serum. The symptoms of Wilson's disease, that is characterized by low levels of ceruloplasmin with subsequent copper deposition in various tissues including brain, often mimic those of schizophrenia. Ceruloplasmin is an acute phase reactant, whose concentration increases in inflammation, infection, trauma, etc. For these properties it is known as an antioxidant. Alterations in ceruloplasmin levels are currently regarded as one of the mechanisms underlying the development of a number of neurodegenerative disorders. Vassiliev et al (2005) discussed largely ceruloplasmin in neurodegenerative diseases [1]
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