High C-Reactive Protein (CRP) Levels as Risk Factors for Poor Sleep Quality in Patients with Nasopharyngeal Cancer with Radiotherapy

Abstract

Background/aim: Good sleep quality affects the body's metabolism, which impacts a person's physical and psychological condition. Patients with nasopharyngeal cancer who receive radiotherapy are reported to experience a lot of poor sleep quality, which will affect the success of treatment, increase treatment costs and decrease quality of life, which will cause social problems in the community future. Rate C-Reactive Protein (CRP) serum in nasopharyngeal cancer patients with radiotherapy increased significantly after radiotherapy. This study to Proving rate of CRP is a risk factor for poor sleep quality in nasopharyngeal cancer patients with radiotherapy Method: This is a statistical analytical study with a case-control design in nasopharyngeal cancer patients with radiotherapy at Prof. Dr. IGNG Ngoerah Hospital Denpasar, Bali, from December 2020 to April 2021. Data analysis using SPSS for Windows. Results: There were 120 respondents, 77.5% male, mean age ± SD 52.85 ± 6.35, high CRP levels on average with poor sleep quality 16.95 ± 6.95 mg/L. Bivariate analysis using Chi-square obtained OR = 9.33 (95% CI 2.18-39.9; p = 0.003). The results of multivariate analysis showed that the CRP level variable had p=0.003. There is a significant relationship between high CRP levels and poor sleep quality. Conclusion: High CRP levels increase the risk of poor sleep quality nine times in nasopharyngeal cancer patients with radiotherapy Keywords: poor sleep quality, CRP, nasopharyngeal cancer, radiotherapy