Abstract
The mouse micronucleus test was conducted to investigate the effect of high body temperature on micronucleus induction. Groups of 10 male ddY mice were exposed to 30°C for 1, 3 or 6 h, 37°C for 0.5, 1, 2, 3 or 4 h, and 40°C for 1 or 2 h. Bone marrow cells were sampled 24 h after heat exposure. Exposure of mice to 37°C for 3 or 4 h and 40°C for 1 or 2 h raised body temperature to approximately 40.5°C and produced statistically significant increases in micronucleated polychromatic erythrocyte frequencies (8.1±4.5, 6.0±2.1, 5.3±3.3, 7.5±2.9‰, respectively; control frequencies, 2.0±1.1‰). In addition, about 25% of the induced micronuclei were relatively large (diameter of micronucleus ≥1/4 diameter of cytoplasm). These results suggest that body temperatures of 39.5°C or higher for more than 30 min induce micronuclei in bone marrow cells, and one possible mechanism is disturbance of the mitotic apparatus.
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