Abstract
The aim of this study was to assess the association between body adiposity with adipokines and with insulin resistance in non-dialysed CKD patients. This is a cross-sectional study including CKD patients under regular treatment in an outpatient clinic. Glomerular filtration rate was estimated by MDRD equation (eGFR). The nutritional status was assessed by BMI, total body fat (BF; dual-energy X-ray absorptiometry), midarm muscle circumference and serum albumin. Laboratorial parameters included serum glucose, triglycerides; leptin and insulin (radioimmunoassay); high molecular weight adiponectin (HMWAdipo; ELISA). The insulin resistance was assessed by HOMA-IR. Data are expressed as mean + SD. One hundred and thirty four CKD patients (male=56%; eGFR= 29±13ml/min.; 65±12 years old) were included. None of the patients presented protein energy wasting and most of them had BMI≥25kg/m 2 (overweight/obese group: OwOb) ( n = 72; 54%). BMI was correlated with BF ( r = 0.74; p r = 0.58); HOMA-IR ( r = 0.36) and HMWAdipo ( r = −0.45). HOMA-IR was associated with leptin ( r = 0.28) and with HMWAdipo ( r = −0.29) (P In conclusion, BMI and BF were associated with increased leptin and HOMA-IR, but with decreased HMWAdipo. The OwOb CKD patients presented higher risk for metabolic and cardiovascular disorders.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
