Abstract
Research on ion channels are traditionally performed in the DC regime. Only a few attempts having been made to conduct RF measurements for probing ion channel properties. We present here simulations and subsequent measurements of an integrated coplanar waveguide and microfluidic tank circuit detecting bilayer formation. We observe a 5 MHz shift in resonant frequency and a 1.4 dB shift in amplitude when a lipid bilayer is formed. These measurements allow for in-vitro radio frequency recordings with nanosecond readout times. The designed structure also enables the incorporation of simultaneous RF and DC recordings from lipid bilayer embedded proteins such as ion channels.
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