Abstract
Anti-infective surfaces are a modern strategy to address the issue of infection related to the clinical use of materials for implants and medical devices. Nanocoatings, with their high surface/mass ratio, lend themselves to being mono-layered on the material surfaces to release antibacterial molecules and prevent bacterial adhesion. Here, a “layer-by-layer” (LbL) approach to achieve a self-assembled monolayer (SAM) with high microbicidal effect on hydroxylated surfaces is presented, exploiting the reaction between a monolayer of thiolic functions on glass/quartz surfaces and a newly synthesized derivative of the well-known antibacterial compound silver sulfadiazine. Using several different techniques, it is demonstrated that a nano-monolayer of silver sulfadiazine is formed on the surfaces. The surface-functionalized materials showed efficient bactericidal effect against both Gram-positive and Gram-negative bacteria. Interestingly, bactericidal self-assembled nano-monolayers of silver sulfadiazine could be achieved on a large variety of materials by simply pre-depositing glass-like SiO2 films on their surfaces.
Highlights
Bacterial infections associated with the use of medical devices are a heavy worldwide health issue, with serious clinical repercussions involving an enormous number of people [1]
The reaction thiols on the surface and Ag-sulfadiazine maleimide (SDM) 2 leads to the self-assembly of a monolayer covalently attachedbetween to the modified glass, sketchedand in Scheme
Samples were prepared on the same silicon crystals used for ATR measurements, with a procedure identical to that applied to the glass slides
Summary
Bacterial infections associated with the use of medical devices are a heavy worldwide health issue, with serious clinical repercussions involving an enormous number of people [1]. These infections commonly result from the irreversible adhesion of bacteria to the device surfaces, often leading to biofilm growth [2], and remarkably resist both the immune defenses and systemic antibiotic therapies. As they are usually inherently protected from antibacterial natural and medical weapons, it’s a good strategy to prevent bacteria growth from the beginning. The first choice should be to modify medical device inorganic surfaces with coatings of antibacterial agents, in order to limit bacteria presence in the surrounding of surfaces [3].
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