Abstract
In this work, the affinity of copper to create a soluble coordination complex with creatinine was exploited for the electrochemical detection of creatinine levels in serum. High aspect ratio copper nanowires were synthesized by controlled hydrothermal method in the presence of dextrose and octadecyl amine. Disposable screen-printed electrode modified with copper nanowires demonstrated excellent sensing towards creatinine in 0.1 M phosphate buffer with a wide detection range of 50–500 µM. The developed sensor was found to be highly selective even in the presence of interfering molecules like glucose, ascorbic acid, urea, uric acid, and chloride. The proposed copper nanowire-based non-enzymatic creatinine sensor is highly promising for point-of-care testing applications.
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