Abstract
This multicenter, open-label study aimed to determine the safety and functional outcome of a high-addition segmented refractive bifocal intraocular lens (IOL) in late inactive age-related macular degeneration (AMD). Twenty eyes of 20 patients were enrolled and followed until 12 months after the intervention. Patients underwent cataract surgery with implantation of a LS-313 MF80 segmented refractive bifocal intraocular lens with a near addition of +8.0 D (Teleon Surgical Vertriebs GmbH, Berlin, Germany). The main outcome measures were distance corrected near visual acuity (DCNVA) and safety as determined by intra- and post-operative complications. Secondary outcomes included distance corrected visual acuity (CDVA), uncorrected distance visual acuity (UDVA), uncorrected near visual acuity (UNVA), the need for magnification to read newspaper, preferred reading distance, speed and performance (logRAD), as well as patient satisfaction. Mean DCNVA improved from 0.95 (±0.19) to 0.74 (±0.35) logMAR, until 6 months after surgery, P<0.05. CDVA improved from 0.70 (±0.23) to 0.59 (±0.30) logMAR, UDVA from 0.94 (±0.25) to 0.69 (±0.34) logMAR, UNVA from 1.08 (±0.19) to 0.87 (±0.43) logMAR. The mean need for magnification decreased from 2.9- to 2.3-fold, preferred reading distance from 23 to 20 cm. No intraoperative complications occurred during any of the surgeries. One patient lost > 2 lines of CDVA between 6 and 12 months, in another case, the study IOL was exchanged for a monofocal one due to dysphotopsia and decreased CDVA. Implantation of a segmented refractive bifocal IOL with +8.0 D addition improves near and distance vision in patients with late AMD and has a satisfactory safety profile.
Highlights
Age-related macular degeneration (AMD) is the main cause of blindness in high-income countries [1]
The Age-Related Eye Disease Study (AREDS) classifies AMD depending on the location, size, area and type of drusen, pigmentation and geographic atrophy in a standard macular grid with circles [2]
All patients had late inactive age-related macular degeneration (AMD), which was classified according to the National Institute for Health and Care Excellence (NICE) guideline [3]
Summary
Age-related macular degeneration (AMD) is the main cause of blindness in high-income countries [1]. The Age-Related Eye Disease Study (AREDS) classifies AMD depending on the location, size, area and type of drusen, pigmentation and geographic atrophy in a standard macular grid with circles [2]. The main approach to help patients cope with their reduced vision and enable them to handle everyday tasks is visual rehabilitation with external low-vision aids like spectacles, hand-held telescopes or magnifiers. Such aids have several drawbacks, reducing the visual field, restricting movement and the necessity of extensive training in the use of the aids [6]
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