Abstract
BackgroundOral squamous cell carcinoma is an important cause of death and morbidity wordwide and effective prognostic markers are still to be discovered. HIF1α protein is associated with hypoxia response and neovascularization, essential conditions for solid tumors survival. The relationship between HIF1α expression, tumor progression and treatment response in head and neck cancer is still poorly understood.Patients and MethodsIn this study, we investigated HIF1α expression by immunohistochemistry in tissue microarrays and its relationship with clinical findings, histopathological results and survival of 66 patients with squamous cell carcinoma of the lower mouth.ResultsOur results demonstrated that high HIF1α expression is associated with local disease-free survival, independently from the choice of treatment. Furthermore, high expression of HIF1α in patients treated with postoperative radiotherapy was associated with survival, therefore being a novel prognostic marker in squamous cell carcinoma of the mouth. Additionally, our results showed that MVD was associated with HIF1α expression and local disease relapse.ConclusionThese findings suggest that HIF1α expression can be used as a prognostic marker and predictor of postoperative radiotherapy response, helping the oncologist choose the best treatment for each patient.
Highlights
High expression of HIF1a in patients treated with postoperative radiotherapy was associated with survival, being a novel prognostic marker in squamous cell carcinoma of the mouth
These findings suggest that HIF1a expression can be used as a prognostic marker and predictor of postoperative radiotherapy response, helping the oncologist choose the best treatment for each patient
These findings suggest that HIF1a expression can be used as a prognostic marker and a tool for choosing the best treatment for each patient
Summary
Oral squamous cell carcinoma is a solid tumor that relies on a hypoxia cellular response system for tumor progression [6,7,8,9,10,11,12]. Hypoxia-inducible factor-1 (HIF1) is a heterodimeric transcriptional complex that functions as the main regulator of systemic and cellular oxygen homeostasis [16,17,18,19,20,21,22,23,24,25]. Oral squamous cell carcinoma is an important cause of death and morbidity wordwide and effective prognostic markers are still to be discovered. The relationship between HIF1a expression, tumor progression and treatment response in head and neck cancer is still poorly understood
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