HIF-1 inhibitor PX-478 for cancer therapy and other fields

Abstract

Hypoxia-inducible factor 1-alpha (HIF-1) is a crucial transcription factor for tumor growth and progression. PX-478, a small molecule HIF-1 inhibitor, has been extensively studied for its potential as an anti-cancer agent in preclinical studies. This paper provides an overview of the current status of PX-478 in cancer treatment, with a focus on its application in treating pancreatic ductal adenocarcinoma (PDAC), lung cancer, breast cancer, glioma, and other kinds of cancer. This article discusses the mechanisms of action, pharmacokinetics, and pharmacodynamics of PX-478, as well as the findings of preclinical and clinical studies conducted to date. The evidence suggests that PX-478 has promising potential as a therapeutic agent for various cancer types. However, further research is needed to fully comprehend the compound's potential benefits and limitations and its optimal clinical application.