Abstract
AbstractExcess protein‐bound uremic toxins (such as indoxyl sulfate [IS]) in the blood could aggravate chronic kidney disease and also predispose to serious cardiovascular disease. In this study, we constructed a novel IS adsorbent polyacrylonitrile/MIL‐101(Cr) (PAN‐M) nanofibrous membrane with high adsorption capacity and ultra‐fast sorption rate for IS. The porous metal–organic framework MIL‐101(Cr) were embedded in PAN nanofibers by electrospinning as an adsorbent for easy recovery. It was found that MIL‐101(Cr) had a strong electrostatic effect on the SO3− of IS and could reach the adsorption equilibrium within 5 min. Notably, MIL‐101(Cr) showed an extremely high adsorption capacity (~170 mg/g) for IS. The MIL‐101(Cr) loading of prepared PAN‐M nanofibrous membrane was optimized at 60 wt% and the optimal PAN‐M60 exhibited an appreciable IS adsorption capacity (103 mg/g). The removal of IS was enhanced from 35.4% to 62.5% during hemodialysis by using PAN‐M60 as adsorbent immersed in dialysate. This efficient adsorption performance can greatly reduce the consumption of dialysate and may shorten the hemodialysis time. This work would provide a fresh perspective on the development of MOF‐based adsorbents to improve hemodialysis therapies.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
