Abstract
In-Vitro Dissolution Study and Shelf Life Calculation of Developed Sol-To-Gel Ocular Drug Delivery System of Brimonidine for Conjunctivitis during Accelerated Stability StudyManu Babbar, Kanchan Kohli, Anil Bhandari
Highlights
Mathematical models play a crucial role in the interpretation of drug release mechanism (Gouda et al, 2017; Grassi et al, 2006; Paarakh et al, 2018; Varma et al, 2004)
Frequentist approach quantify the properties of data-derived quantifies, as for Bayesian approach quantify the incertitude of measure (VanderPlas, 2014)
In vitro dissolution tests have shown that the prepared suppositories have an sustained-release effect, even if it does not contain Eudragit
Summary
Mathematical models play a crucial role in the interpretation of drug release mechanism (Gouda et al, 2017; Grassi et al, 2006; Paarakh et al, 2018; Varma et al, 2004). The appropriate model for each formulation is selected based on the highest Rsq (Adjust) and the lowest Akaike Information Criterion (AIC) (Gouda et al, 2017; Paarakh et al, 2018; Victor and Francis, 2017). Such a situation may lead to variation in the best-fitting model among formulations, in particular when the number of points in the curve is limited. Frequentist approach quantify the properties of data-derived quantifies, as for Bayesian approach quantify the incertitude of measure (VanderPlas, 2014)
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