Abstract
Stimuli-responsive polymers have been widely studied because of their potential use in nanocarriers and nanocontainers. In this study, a smart multistimuli responsive system was prepared through a light controlled supramolecular assembly. Mono cyclodextrin substituted isobutyl polyhedral oligomeric silsesquioxane (mCPOSS), an amphiphilic molecule, was synthesized by copper(I)-catalyzed azide–alkyne cycloaddition (CuAAC), while azobenzene end-capped poly(ethylene glycol)-b-poly(2-(dimethylamino)ethyl methacrylate) copolymer (PEG-b-PDMAEMA-azo, PPA), a biocompatible pH/temperature-responsive macromolecule, was synthesized by atom transfer radical polymerization and CuAAC. The self-assembly process of PPA and mCPOSS in aqueous solution was as followed: first, mCPOSS self-assembled into a nanosphere in aqueous solution because of its amphipathic property; then, the trans-azo end groups of the PPA interacted with the cyclodextrin cavities on the nanosphere, and complex micelles were formed by the supramolecula...
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