Abstract
The aim of the present investigation was to determine the effectiveness of 1 daily s.c. injection for 5 consecutive days of GHRH 1-44 (1 mcg/Kg) on the plasma hGH response to an i.v. bolus of GH-RH 1-44 (1 mcg/Kg) in hypopituitary patients who had a subnormal response of plasma hGH to previously performed tests: ITT, clonidine, sleep. The i.v. GH-RH test was performed before (I) and day after (II) the last i.m. injection.Eleven children (7 IGHD, 4 HPHD) were studied. According to the results the patients were sub-divided into 3 groups:In GR I 3 girls were in puberty and thepeak response of hGH to other tests was 5.1±1.9. In GR II 4 boys were prepubertal, had a lower peak of hGH in other tests 2.3±0.9, whereas in GR III there was no rise in any test. This investigation indicates a) that repeated administration of GH-RH even in small doses is useful in the differentiation of patients who may benefit from prolonged therapy; b) that hGH responsiveness to GH-RH may be influenced by sex hormones.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
