HFIP-promoted synthesis of imidazo [1,2-a]pyridines containing CF3-substituted tertiary alcohols at room temperature

Abstract

Herein, we introduce a facile and efficient method for the synthesis of imidazo [1,2-a]pyridines containing CF3-substituted tertiary alcohol moieties using trifluoropyruvates as synthons under metal-free reaction conditions. The reaction promoted by the HFIP proceeds well at room temperature, displaying good to satisfactory yields and high functional group tolerance. Some advantages of the protocol are mild reaction conditions, simple operation and ready scalability.