Abstract

Hexachlorophene (HCP) concentrations in the blood of human adults were measured by gas-liquid chromatography to establish a baseline value and to determine the effects of using products containing from 0·5 to 30% HCP. The mean baseline concentration in 30 control subjects was 0·02 μg HCP/ml of blood. Values ranged from 0·38 μg/ml in an individual using a 3 % HCP cleanser for whole-body washing to less than 0·005 μg/ml (limit of detection) in some individuals using 1 or 3% HCP cleansers for hand-washing only. HCP concentrations resulting from prolonged use of a soap containing 0·75 % HCP ranged from 0·02 to 0·14 μg/ml while those resulting from the use of a mouthwash containing 0·5% HCP for 3 wk ranged from 0·02 to 0·12μg/ml. The mean concentrations in human adipose tissue obtained from the neck and abdomen were 0·01 and 0·04 μg/g of tissue, respectively.

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