Abstract
Diverse pharmacological activities and reliable clinical performances of Chinese herbal medicines have attracted worldwide attention in terms of its modernization. Here, a hexa-herbal Chinese formula (HHCF) for treating eczema topically has been studied from both chemical and biological perspective. It consists of roots of Scutellaria baicalensis Gerogi, Rheum officinale Baill., Sophora flavescens Aiton; root's bark of Dictamnus dasycarpus Turcz.; bark of Phellodendron chinense C.K. Schnied and fruit of Kochia scoparia (L.) Schard.. To evaluate the anti-inflammatory effects of the hexa-herbal decoction for treating eczema, the anti-infective and hyaluronidase-inhibitory effects were studied. Hyaluronidase is liberated during skin inflammation that degrades hyaluronic acid (HA) distributed in the extracellular matrix into pro-inflammatory low molecular weight HA fragments. [1,2] Besides, Staphylococcus aureus colonizes the skin of most patients with AD and produces superantigens that could further increase severity of AD via subverting T-regulatory cell activity and inducing corticosteroid resistance. [3] Therefore, activity of the decoctions prepared from mixture and individual medicinal plants of the formula against S. aureus and also Bacillus subtilis, Escherichia coli and Pseudomonus aeruginosa were tested. HHCF demonstrated anti-hyaluronidase activity in a dose-dependence manner. However, no anti-bacterial activity was observed. Metabolic fingerprints for the HHCF and a series of preparation each lacking one of the six drugs were obtained using 1H Nuclear magnetic resonance, coupled with principal component analysis (PCA), in order to group preparations with similar chemical profile. Decoctions prepared by excluding Sophora, Kochia or Phellodendron showed strong differences from the HHCF; indicating the chance of these herbs in the formula for its biological activity.
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