Abstract
P2X4 and P2X7 receptors are cation channels expressed in immune cells. They are activated by binding ATP released from damaged and inflamed tissue and are involved in inflammation and pain sensation. Whether P2X4 and P2X7 receptors assemble exclusively as homotrimers or also as P2X4-P2X7 heterotrimers is controversial. To clarify this, we cloned concatamers encoding heterotrimers of P2X4 and/or P2X7 subunits in permutated arrangement. We expressed these concatamers in X. laevis oocytes and investigated their function by recording ATP-induced whole cell currents using two-electrode voltage clamp.
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