Abstract
Abstract Heteroptera belongs to a group of highly diversified insect forms ranging from plant feeders, blood-feeders, predators, scavengers, detritivores, and fungivores with terrestrial or aquatic habitats. These insects have been used in entomophagy and entomotherapeutic practices. Edible insects are a source of essential bioactive secondary metabolites and bioactive peptides, having nutraceutical potential to deal with metabolic disorders. Various venomous peptides from heteropterans with therapeutic properties have been reported and are constantly being investigated for various medical conditions. This review enlists heteropteran edible insects and bioactive peptides identified from heteropterans for use as an alternative medicine. The heteropteran categories and feeding habits have been briefly outlined. The role of bioinformatics in putting up a translational aspect of insect venom has been discussed. Further, the possible exploration of therapeutic function-based proteins and peptides and the need for advanced studies using modern bioinformatics tools, and scientific validation processes are also discussed.
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