Abstract
This paper describes a one-pot three-component Mannich reaction, catalyzed by phosphotungstic acid (H3PW12O40), a heteropoly acid in ionic liquid. The catalyst was found to be mild and efficient, and the protocol affords β-amino ketones in good yields under ambient conditions. Several ionic liquids and conventional organic solvents were employed for the reaction. The ionic liquid 1-butyl-3-methylimidazolium tetrafluoroborate ([bmim]BF4) offered the best results in terms of yield of the products. It was observed that a homogeneous reaction medium proved beneficial for the yield of the reaction.Key words: Mannich reaction, β-amino ketones, phosphotungstic acid, ionic liquid, recyclability.
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