Abstract
Titers of several heterophilic antibodies have been found elevated following the administration of blood group substance A through blood transfusion. These antibodies include sheep agglutinins, beef hemolysins, beef agglutinins, and occasionally sheep hemolysins. The titers of the first two antibodies which are consistently elevated also in infectious mononucleosis may be a source of error in the serologic diagnosis of this disease. However, antibodies in the two conditions can be differentiated by absorption with: 1) guinea pig kidney and beef erythrocytes, as is done in the differential test; 2) blood group substance A which removes completely the antibodies that follow immunization with substance A but not in infectious mononucleosis. We could find no evidence to indicate that heterophilic antibodies in infectious mononucleosis are produced against the host's blood group antigens.
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