Heterologue Skin Microbiota Transplantation for Treatment of Sarcoptic Manges in Two Dogs with Zoonotic Transmission

Abstract

In the present case report, the authors inspected the feasibility of transferring unenriched (however moistured and pre-biotic treated) skin microbiota communities between two heterologous hosts, namely heterologue skin microbiota transplantation (hSmT), [from apparently healthy donor to other relevant and diseased dogs, with scabies, separately]. Two cross-bred, client-owned dogs (belonging to the same owners) with a diagnosis of scabies and intense pruritus were enrolled. Nivea Clear Up Strips were attached in a total of 3 various apparently healthy integumentary tissue of another donor dog and allowed to dry for 10-12 minutes. This was followed by peeling off, all 3 strips were then transferred to diseased skin tissue (laterolateral area in 2 dogs with scabies, separately) which were also irrigated with isotonic and allowed to attach for at least 12-15 minutes. Finally, all 3 strips were removed. Both in case I and II, Vas pruritus scores were decreased significantly beginning on day 0 (initial hSmT day) to days 21. Vas pruritus score ranged between 8-10 and 7-9, in case I and II, respectively, prior to hSmT [days -14 to day 0]. Prior to hSmT all skin scrape positivity were deemed available on days -14 to 0, whereas after day 2 of hSmT, all 2 dogs gave negative skin scraping results till the end of the study. It should not be unwise to draw preliminary conclusion that transfer of unenriched skin microbiota from a healthy donor to the diseased dogs with scabies, should have helped hastening clinical and parasitological recovery by manipulation of cutaneous microenvironment