Heterogeneous Turnover of Myofibrillar Protein

Abstract

TO investigate the heterogeneity of turnover of proteins of the myofibril, we developed “a continuous double isotope method” which is a modification of the continuous isotope administration method. The assumptions involved in the use of the double isotope method, proposed by Schmike1, are not applicable in the case of proteins of the myofibril because these proteins did not follow the simple exponential decay kinetics as shown by the single isotope administration method2.