Abstract
Heterogeneous nuclear ribonucleoproteinK (hnRNPK) is one of the major pre-mRNA-binding proteins, that is involved in translational modifications. In our previous studies, we found that hnRNPK is associated with human gastric cancer. The protein levels of hnRNPK were detected in cell lines and tissue microarrays. The correlation between hnRNPK expression and patient survival rate was evaluated by Kaplan-Meier survival analysis. In addition, we also detected hnRNPK expression in preoperative and postoperative serum samples from patients with gastric cancer, and serum samples from healthy volunteers. We found that hnRNPK was overexpressed in the gastric cancer cell lines. The levels of hnRNPK were significantly elevated in the gastric cancer tissues compared with that noted in the tumor-adjacent gastric mucosal and normal gastric mucosal sampes, and hnRNPK expression was found to correlate with tumor stage and lymph node metastasis. However, the level of serum hnRNPK did not differ significantly between gastric cancer patients and healthy volunteers. We also found that patients whose tumors showed elevated expression of hnRNPK had poor survival. The present study suggests that hnRNPK is a promising tissue biomarker for diagnosing gastric cancer and is a prognostic indicator for patients with gastric cancer.
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