Abstract
A novel heterogeneous interpenetrating polymer networks system has been developed to provide versatile drug release. This system consists of two chemically independent crosslinked polymers in which the proportions and properties of both polymers can be independently varied. The first network is a hydrophobic polyurethane network while the other consists of a hydrophilic/hydrophobic balanced vinyl network. Two critical parameters, the crosslinking density of the polyurethane network and the hydrophilicity of the vinyl network, can be varied to generate desired release kinetics for a given drug from disk-shaped devices. By varying these two parameters, first-order, pseudo-zero order release kinetics, or bimodal release patterns could be obtained. It is hypothesized that the balancing of the network elasticity and the osmotic swelling pressure induced by water soluble drugs (osmotically active solutes) incorporated into the matrices is involved in the unusual release properties observed with these matrices. However, with drugs of low aqueous solubility, other effects, such as microphase separation and network hydration kinetics, may also be involved.
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