Abstract
AbstractWe communicate a convenient method for the pressure hydrogenation of quinolines in aqueous solution by using a particulate cobalt-based catalyst that is prepared in situ from simple Co(OAc)2·4H2O through reduction with abundant zinc powder. This catalytic protocol permits a brisk and atom-efficient access to a variety of 1,2,3,4-tetrahydroquinolines thereby relying solely on easy-to-handle reagents that are all readily obtained from commercial sources. Both the reaction setup assembly and the autoclave charging procedure are conducted on the bench outside an inert-gas-operated containment system, thus rendering the overall synthesis time-saving and operationally very simple.
Highlights
We communicate a convenient method for the pressure hydrogenation of quinolines in aqueous solution using a particulate Co-based catalyst that is prepared in-situ from simple Co(OAc)2 · 4 H2O through reduction with abundant zinc powder
This catalytic protocol permits a brisk and atom-efficient access to a variety of 1,2,3,4-tetrahydroquinolines thereby relying solely on easy-to-handle reagents that are all readily obtained from commercial sources
We reported on a solid cobalt catalyst which was generated in-situ through reduction of simple hydrated Co(OAc)[2] with harmless zinc powder and that brought about the same catalytic transformation.[43]
Summary
Submission Date: Accepted Date: Publication Date: 2021-07-09 2021-09-14 2021-09-27. Heterogeneous Hydrogenation of Quinoline Derivatives Effected by a Granular Cobalt Catalyst. Conflict of Interest: The authors declare that they have no conflict of interest.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
