Abstract
6730 Background: Waldenstrom's macroglobulinemia (WM) is a B-cell malignancy, recently established by a consensus panel to be represented by the underlying WHO/REAL pathological diagnosis of IgM secreting lymphoplasmacytic lymphoma (Semin Oncology 30:110, 2003). The expression of CD5, CD10, and CD23 in WM remains controversial, and confusion with other B-cell malignancies has often resulted. Methods: We examined the expression of CD5 (L17F12 mAb), CD10 (J5 mAb), and CD23 (EBVCS-5 mAb) by multicolor flow cytometry on bone marrow lymphoplasmacytic lymphoma cells (CD19+, LC restricted) taken from patients with a consensus panel defined diagnosis of WM, and correlated these findings with important clinical and laboratory features at presentation. Results: Antigen expression was as follows: CD5 (10.7%; N=103); CD10 (10.1%; N=89); and CD23 (20%; N=60). No significant differences in age, serum IgM, serum viscosity, and beta 2 microglobulin levels, as well as complete blood counts were observed in patients with a...
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