Abstract
The precise topographical distribution of dopamine D 2 receptors in the rat striatum has been studied autoradiographically through the use of [ 3 H] N-n- propylnorapomorphine (NPA) as a ligand. The highest densities of [ 3H]NPA binding sites were found in the ventrolateral aspect and medial margin of the striatum, while sparse grain densities were present in the medial and latero-dorsal striatum. Moreover, a clear gradient of [ 3H]NPA binding was observed along the rostro-caudal axis of the striatum. These heterogeneities in the distribution of dopamine receptors provide further evidence for a functional compartmentalization of the striatum.
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