Abstract
Abstract The modifier concentration dependence of rate and enantioselectivity (ee) was investigated of the diethyl-2-oxoglutarate (EOG) and pyruvaldehyde dimethyl acetal (PADA) hydrogenations catalyzed by cinchona alkaloid modified Pt-alumina catalysts. Using the E 4759 catalyst in acetic acid under mild experimental conditions (room temperature, hydrogen pressure 1 bar) an optical yield of 95–97% can be achieved. Recent studies on activated ketones of different structures (EtPy: ethyl pyruvate, EOG, EBF: ethyl benzoylformate, PADA) carried out under identical experimental conditions have called attention to the role of additional factors to be considered for the interpretation of the mechanism of Orito’s reaction.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
