Abstract
In experiments on induction of tolerance to xenogeneic cells in newborn mice with rat bone marrow cells, higher mortality was not observed even after repeated injection of cells, hence no graft-versus-host disease (GVHD) occurred. Xenogeneic skin grafts were not tolerated and showed little significant prolongation of survival. Nevertheless, complete suppression of cytotoxic antibody formation was detectable in most of the treated animals in which no graft survived longer than 12 days. At the cellular level, complete tolerance in MLC and cytotoxicity assays was also observed in the majority of animals. Thus, different detection systems seem to be a decisive criterion in detecting the tolerance state and the individual specific mechanisms of immunity may be dissociated in the split tolerance studied in the xenogeneic system in the present experiments.
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