Abstract
Methods Quantitative CMR perfusion was performed at 1.5T in 17 healthy volunteers under baseline (rest) and adenosine hyperemia (stress). Median filters with different kernel size were used to estimate MBF at different resolutions (0.07 g, 0.27 g, 0.61 g, 1.1 g of myocardium). MBF heterogeneity was evaluated as the relative dispersion ([RD] = standard deviation/mean) on basal- and mid-ventricular slices for each subject. Paired t-tests and linear mixed-models were used to account for withinsubject effects. Results All normal volunteers had Framingham scores <1%. MBF at rest was 1.1 ml/g/min (95% CI: 0.9 to 1.2 ml/g/ min) vs. adenosine stress 2.8 ml/g/min (95% CI: 2.4 to 3.1 ml/g/min [p < 0.001]). At the intrinsic image acquisition resolution (1 voxel = 0.07 g), the RD was 13.0% (95% CI: 11.7 to 14.3%) at rest vs. 15.9% (95% CI: 14.1 to 17.7%) at adenosine stress (p = 0.004). For increasing voxel sizes, the RD of MBF under rest and stress conditions decreased in a highly-significant pattern (Figure 1). There were no detectable differences in pairwise comparisons of RD between basal and mid-slices at rest or under hyperemic conditions (all p = NS).
Highlights
An accurate description of the heterogeneity in myocardial blood flow (MBF) by CMR is needed for understanding the physiology of perfusion variability
Quantitative CMR perfusion was performed at 1.5T in 17 healthy volunteers under baseline and adenosine hyperemia
Healthy myocardium displays resolution-dependent hetereogeneity of MBF at rest that increases during hyperemia
Summary
Heterogeneity of resting and hyperemic myocardial blood flow in healthy volunteers: a quantitative CMR perfusion pixel-map study. Anders M Greve1*, Li-Yueh Hsu, Sujethra Vasu, W Patricia Bandettini, Andrew E Arai. From 17th Annual SCMR Scientific Sessions New Orleans, LA, USA. From 17th Annual SCMR Scientific Sessions New Orleans, LA, USA. 16-19 January 2014
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.