Abstract
Obesity is associated with numerous metabolic disorders, the development and progression of a wide range of conditions and diseases, primarily cardiovascular disease and type 2 diabetes. One of the widely discussed phenomena of the association of obesity with cardiovascular diseases, their complications and mortality is the phenomenon of “heterogeneity of obesity phenotypes in relation to cardiovascular risk”. Currently, two main phenotypes have been identified — metabolically healthy and metabolically unhealthy obesity. At the same time, not only the expediency of separation, but also the existence of this phenotype is widely discussed today. The article provides an overview of existing approaches to the verification of metabolic phenotypes of obesity and data relating to the epidemiology and the association of metabolically healthy obesity with the risk of cardiovascular diseases and death, and also discusses the factors that determine the features of the obesity phenotype.
Highlights
Obesity is associated with numerous metabolic disorders, the development and progression of a wide range of conditions and diseases, primarily cardiovascular disease and type 2 diabetes
The article provides an overview of existing approaches to the verification of metabolic phenotypes of obesity and data relating to the epidemiology and the association of metabolically healthy obesity with the risk of cardiovascular diseases and death, and discusses the factors that determine the features of the obesity phenotype
Выделение различных фенотипов ожирения должно быть обусловлено необходимостью верификации пациентов с высоким сосудистого риска (ССР) для своевременного начала проведения комплекса лечебно-профилактических мероприятий по предупреждению развития или прогрессирования ассоциированных состояний и заболеваний, а также направленных на редукцию и восстановление физиологических функций жировой ткани
Summary
Obesity is associated with numerous metabolic disorders, the development and progression of a wide range of conditions and diseases, primarily cardiovascular disease and type 2 diabetes. Heterogeneity of obesity phenotypes in relation to cardiovascular risk Druzhilov M.
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