Abstract
<p indent="0mm">Natural killer (NK) cells have attracted much attention since their discovery in the 1970s; however, earlier studies mainly focused on circulating NK cells. In the past decade, the heterogeneity of NK cells in different tissues has begun to attract increasing attention. As an organ containing abundant and heterogeneous NK cell populations, the liver provides a good window for studying them. It is now commonly accepted that bulk liver NK cells comprise circulating conventional NK cells and liver-resident NK cells. This review summarized and discussed the developmental origin, differentiation, transcriptional regulation, and immune functions of liver-resident NK cells and conventional NK cells, providing new perspectives for studying liver regional immunity.
Published Version (
Free)
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
