Heterogeneity of cartilage involvement in knees with radiographic disease severity Kellgren-Lawrence 2 and 3: the most study

F Roemer,D.T Felson,J.J Stefanik,G Rabasa,M.D Crema,N Wang,T Neogi,J.A Lynch,M.C Nevitt,J Torner,C.E Lewis,A Guermazi

doi:10.1016/j.joca.2021.02.433

Heterogeneity of cartilage involvement in knees with radiographic disease severity Kellgren-Lawrence 2 and 3: the most study

F Roemer, D.T Felson + Show 10 more

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https://doi.org/10.1016/j.joca.2021.02.433

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Journal: Osteoarthritis and cartilage	Publication Date: Apr 1, 2021
License type: publisher-specific-oa

Affiliation: Boston University, University of Erlangen-Nuremberg, Northeastern University, University of California, San Francisco, University of Iowa, University of Alabama at Birmingham

#Disease-modifying Osteoarthritis Drug #Disease-modifying Osteoarthritis Drug Trial + Show 8 more

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Abstract

Purpose: Imaging plays an important role in defining structural disease severity and potential suitability of patients recruited to disease-modifying osteoarthritis drug (DMOAD) trials. A common target tissue of DMOADs is cartilage and structural success of a clinical trial is usually defined by reduced cartilage loss or increase in cartilage thickness compared to placebo, commonly in the medial tibio-femoral joint (TFJ). To be eligible for inclusion into a DMOAD trial from a structural perspective, knees with Kellgren-Lawrence (KL) grades 2 and 3 are typically included.

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