Abstract
Using the in situ DNA nick end-labeling method and immunohistochemistry, the indices of apoptosis (AI) and Ki-67 labeling index (LI) among 3 different portions within the tumor (the central surface vs. the lateral margin or deepest portion) were determined and compared in 14 superficial spreading type early gastric cancers. The AI was the lowest and the LI remained high in the lateral margin compared with the central surface, whereas the AI remained high and the LI was the lowest in the deepest portion. This heterogeneity of apoptosis and proliferation within the tumor might be related to the predominantly horizontal growth of superficial spreading type early gastric cancer.
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