Abstract
BackgroundLivestock trypanosomiasis, transmitted mainly by tsetse flies of the genus Glossina is a major constraint to livestock health and productivity in the sub-Saharan Africa. Knowledge of the prevalence and intensity of trypanosomiasis is important in understanding the epidemiology of the disease. The objectives of this study were to (a) assess the prevalence and intensity of trypanosome infections in cattle, and (b) to investigate the reasons for the heterogeneity of the disease in the tsetse infested districts of Amuru and Nwoya, northern Uganda.MethodsA cross-sectional study was conducted from September, 2011 to January, 2012. Blood samples were collected from 816 cattle following jugular vein puncture, and screened for trypanosomes by HCT and ITS-PCR. A Pearson chi-squared test and logistic regression analyses were performed to determine the association between location, age, sex, and prevalence of trypanosome infections.ResultsOut of the 816 blood samples examined, 178 (22 %) and 338 (41 %) tested positive for trypanosomiasis by HCT and ITS-PCR, respectively. Trypanosoma vivax infection accounted for 77 % of infections detected by ITS-PCR, T. congolense (16 %), T. brucei s.l (4 %) and mixed (T. vivax/ T. congolense/T.brucei) infections (3 %). The risk of trypanosome infection was significantly associated with cattle age (χ2 = 220.4, df = 3, P < 0.001). The highest proportions of infected animals were adult males (26.7 %) and the least infected were the less than one year old calves (2.0 %). In addition, the risk of trypanosome infection was significantly associated with sex (χ2 = 16.64, df = 1, P < 0.001), and males had a significantly higher prevalence of infections (26.8 %) than females (14.6 %).ConclusionOur results indicate that the prevalence and intensity of trypanosome infections are highly heterogeneous being associated with cattle age, location and sex.
Highlights
Livestock trypanosomiasis, transmitted mainly by tsetse flies of the genus Glossina is a major constraint to livestock health and productivity in the sub-Saharan Africa
Uganda is affected by Human African Trypanosomiasis (HAT) caused by two Trypanosoma brucei sub-species: Trypanosoma brucei gambiense in the northwest, and Trypanosoma brucei rhodesiense in the southeast and northeast of the country [1]
Out of the 816 blood samples screened for trypanosome infections, 178 (22 %) and 338 (41 %) animals tested positive by parasitological diagnostic tools (HCT and Direct smears) and Internal Transcribed Spacers (ITS) Polymerase Chain Reaction (PCR), respectively
Summary
Livestock trypanosomiasis, transmitted mainly by tsetse flies of the genus Glossina is a major constraint to livestock health and productivity in the sub-Saharan Africa. The objectives of this study were to (a) assess the prevalence and intensity of trypanosome infections in cattle, and (b) to investigate the reasons for the heterogeneity of the disease in the tsetse infested districts of Amuru and Nwoya, northern Uganda. Trypanosomiasis, caused by several species of Trypanosoma, is an economically important disease affecting both humans and domestic animals. African trypanosomiasis is transmitted mainly by tsetse flies of the genus Glossina known to be distributed widely between latitudes 14°N and 29°S of the equator in 37 SubSaharan countries [1]. Uganda is affected by Human African Trypanosomiasis (HAT) caused by two Trypanosoma brucei sub-species: Trypanosoma brucei gambiense in the northwest, and Trypanosoma brucei rhodesiense in the southeast and northeast of the country [1]. Trypanosoma brucei brucei, Trypanosoma congolense and Trypanosoma vivax are species of economic importance
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