Heterogeneity in DSM-5 Symptom Criteria: Phenotypes of Alcohol Use Disorder in a Sample Seeking Alcohol Treatment.

Abstract

This study sought to identify phenotypic variations among individuals with alcohol use disorder (AUD) that may, in part, help improve the effectiveness of existing AUD interventions. Latent class analysis was conducted to examine the potential heterogeneity of AUD in a sample (N=220; Mage=51.19years, standard deviation=9.94; 37.7% female) of treatment-seeking participants diagnosed with AUD using DSM-5 criteria. Three distinct patterns of responses to the 11 DSM-5 AUD symptoms emerged: Class 1 (n=114, 51.8%), Class 2 (n=78, 35.5%) and Class 3 (n=28, 12.7%). The identified profiles were further differentiated by demographics, alcohol-related constructs, individual difference characteristics and diagnostic and treatment variables. The findings have implications for refining AUD assessment as well as optimizing personalized treatment.