Abstract
Publisher Summary This chapter discusses the heterogeneity and territorial organization of the nuclear matrix and related structures. Nonchromatin structures (NCSs) are structures containing RNA, such as the perichromatin and interchromatin fibrils, granules and nuclear bodies, together with certain nucleolar components, nuclear membrane material, and pore complexes. Several roles of NCS in connection with the maintenance of nuclear organization include (1) the coiling of DNA molecules into superhelical loops, (2) the segregation of chromatin into condensed and diffuse zones, and (3) the positioning of distinct chromosome segments in the nuclear volume. Genetically active sequences occupy definite positions along the DNA loops. The direct involvement of NCSs in gene regulation would only be possible when active genes are located close to the attachment points of the loops. 3D electron microscopy constitutes a powerful approach to verify the existence and distribution of NCSs.
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