Heterocyclic Resveratrol Analogs. Synthesis and Physiological Activity: Part 1–Analogs Obtained by the Replacement of Aryl Residues with Heterocyclic Fragments

Abstract

Resveratrol is a polyphenolic phytoalexin, a stilbene derivative, whose physiological activities have been studied in a large number of studies. It demonstrated antioxidant, antitumor, neuroprotective, anti-inflammatory, antibacterial, and antiviral properties. In the last decade, much attention was paid to the development of resveratrol derivatives with the goal of improving its pharmacological profile and pharmacokinetics. Part 1 of the review is devoted to resveratrol synthetic analogs obtained by the replacement one or two phenyl moieties of the stilbene backbone with bioisosteric heterocyclic fragments. Attention was focused on the methods of synthesis of resveratrol analogs and their biological activity.