Heterocyclic compounds containing thiazole ring as important material in medicinal chemistry

Abstract

Thiazoles are among the most important heterocyclic compounds that contain sulphur at positions 1 and nitrogen at positions 3 in a 5-membered ring. Thiazoles possess an excellent biological activity because of the presence of N and S atoms. These heteroatoms play an important role in the coordination chemistry and bind at active sites of the metal ions which increase their therapeutic activity. Many natural products possess the thiazole ring structure, which has sulphur and nitrogen heteroatoms. Thiamine (vitamin B1) is the most important naturally occurring thiazole derivative in which both pyrimidine and thiazole rings are present. In the present research work, derivatives of 2‐amino thiazol have been synthesized. These ligands were further reacted with Cu salts to synthesise metal complexes. Many of the researchers are interested in the thiazole derivatives and their complexes because of their application as good biological active compounds in antibacterial, antifungal, and antioxidant activity.