Abstract
AbstractCondensation of arylnitrile oxides with α‐amino acid esters, other than those of glycine and analine, has been found to constitute a synthetic route to the hitherto unknown 1,2,4‐oxadiazin‐6‐ones 7. α‐Amino alcohols yield with nitrile oxides the corresponding acyclic N‐(arylhydroxamoyl)amino alcohols, which are also accessible by borohydride reduction of compounds 7. In contrast, the adducts formed from nitrile oxides and α‐amino acids are unstable; they decompose readily into the aldehyde, derived from the amino acid, together with the aldoxime, derived from the nitrile oxide. Both decomposition products are also formed when compounds 7 are subjected to mild hydrolysis.
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