Abstract
AbstractCascade reactions via metal carbene gem-difunctionalization, which are initiated by metal-catalyzed carbene formation, followed by nucleophilic attack to produce ylides or zwitterionic intermediates, and terminated by electrophilic interception by different electrophiles, are useful and practical tools for the synthesis and modification of heterocycles. This method opens a new door for the rapid assembly of complex molecules imbedded with a variety of heterocyclic units in a highly regioselective manner. This chapter summarized the advances in this area contributed by our group and other groups for the efficient synthesis of multi-functional heterocycles via carbene cascade reactions in the literature through 2022; other related advances will be mentioned with a brief comment when necessary.KeywordsCascade reactiongem-difunctionalizationHeterocyclesMetal carbeneYlide intermediateZwitterionic intermediate
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