Heterocycles 26: synthesis, characterisation, and anticancer activity of some thiazolic chalcones

Abstract

Chalcones and their derivatives have been shown to have potent anticancer activity. A series of aldehydes A 1–4 and thiazolic chalcones C 1–20 were synthesized and evaluated for their in vitro cytotoxic activity against three human cancer cell lines. In addition, this work led to the synthesis of 12 new thiazolic chalcones using a base-catalyzed Claisen-Schmidt condensation reaction. Compounds C 10 and C 12 were found to be the most promising biologically active samples with IC50 values below or around 10 µM on both DU-145 and THP-1 cancer cell lines.