Abstract
Epigenetically heritable heterochromatin domains control a variety of chromosomal functions. In addition to stable repression of large pericentric and telomeric domains, heterochromatin plays an essential role in the maintenance of genomic integrity through its role in sister chromatin cohesion and chromosome segregation. Moreover, heterochromatic structure is known to prohibit deleterious recombination between repeated DNA sequences. Finally, the discovery of RNAi being required for targeted heterochromatin assembly has had a significant impact on our current thinking about the mechanisms of higher-order chromatin assembly and genome regulation. Future investigations of RNAi-based chromatin remodeling should lead to an increased understanding of how cells modify their epigenetic landscape in response to distinct developmental signals and under diverse environmental conditions.
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