Abstract
From the reaction of Super Hydride (LiBEt 3H) with 6-(furyl)fulvene ( 1a), 6-(thiophenyl)fulvene ( 1b) or 6-( N-methyl-pyrrole)fulvene ( 1c) the corresponding lithium cyclopentadienide intermediates ( 2a– c) were obtained. These intermediates were reacted with titanium tetrachloride and bis-[(furyl-2-cyclopentadienylmethane)] titanium(IV) dichloride ( 3a) and bis-[(thiophenyl-2-cyclopentadienylmethane)] titanium(IV) dichloride ( 3b) and bis-[( N-methylpyrrole-2-cyclopentadienylmethane)] titanium(IV) dichloride ( 3c) were obtained and subsequently characterised by X-ray crystallography. When titanocenes 3a– c were tested against pig kidney (LLC-PK) cells inhibitory concentrations (IC 50) of 1.6 × 10 −4 M, 1.5 × 10 −4 M and 9.1 × 10 −4 M, respectively, were observed. These values represent improved cytotoxicity against LLC-PK, when compared to their corresponding ansa substituted analogues and also in comparison to unsubstituted titanocene dichloride.
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