Abstract
6-Acetamido-5, 6, 7, 8-tetrahydroquinoline N-oxide (VI) was derived to the 8-oxo derivative (IX) via the acetoxy compound (VII). Introduction of carboxymethyl group by a Witting reaction of IX and catalytic hydrogenation afforded the amido ester (XI). The title compound (XVI) was synthesized from the amino acid ester (XII) by intramolecular cyclization and the subsequent lithium aluminum hydride reduction of the resulting lactam.
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