Herstellung und antivirale Wirksamkeit von Polyacrylsäure und Polymethacrylsäure

Abstract

AbstractThe antiviral activity of a number of fractions of poly(acrylic acid)s and poly(methacrylic acid)s with different tacticities, different molecular weights and molecular weight distributions has been investigated. Isotactic poly(acrylic acid)s are essentially more antiviral active in the whole area of efficacy than the atactic ones. Independent of the tacticity poly(acrylic acid)s with molecular weights smaller than 5000 show no significant effects, polymers with molecular weights greater than 25000 are toxic in the used doses. The optimum of efficacy is between 6000 and 15000. Isotactic poly(acrylic acid)s with narrow molecular weight distributions are more active than those with broad distributions. The atactic poly(acrylic acid)s with lower efficacy do not show this relationship. Atactic poly(methacrylic acid)s are not antiviral active in vivo compared with untreated controls. Isotactic ones have a just detectable efficacy which is essentially lower than the activity of the atactic poly(acrylic acid)s.