Abstract
Human Herpes Virus (HHV) is a DNA virus and is the most important viral pathogen causing intraocular inflammation. HHV is classified into types 1-8. Among these types, HHV-1, HHV-2, HHV-3 Varicella Zoster Virus (VZV) and HHV-5 Cytomegalovirus (CMV) are known to cause herpetic viral retinitis, including acute retinal necrosis and CMV retinitis. Herpes viral retinitis can be diagnosed from characteristic ocular findings and viral identification by PCR of the aqueous humor. Recently, therapy has become more effective than in the past. Herpes viral retinitis gradually progresses if appropriate treatment is not provided with regard to the patient’s immune status. Further advances in diagnostic methods and treatment are required in the future.
Highlights
Human Herpes Virus (HHV) is a DNA virus and the most important viral pathogen causing intraocular inflammation
Herpes viral retinitis can be diagnosed from characteristic ocular findings and viral identification by Polymerase Chain Reaction (PCR) of the aqueous humor
It is classified into types 1-8, among which HHV-1, HHV-2, HHV-3 (Varicella Zoster Virus: VZV) and HHV-5 Cytomegalovirus (CMV) are known causes of herpetic viral retinitis
Summary
Human Herpes Virus (HHV) is a DNA virus and the most important viral pathogen causing intraocular inflammation. The types of retinitis caused by these viruses include acute retinal necrosis, CMV retinitis and progressive outer retinal necrosis. ARN syndrome is infectious retinitis caused by members of the Herpes virus family. It was first described Urayama et al (1971) in 6 patients with acute panuveitis and retinal arteritis that progressed to diffuse necrotizing retinitis and late-onset rhegmatogenous retinal detachment. CMV retinitis is the most common intraocular infection in patients with AIDS, affecting approximately 30% of them at some point in the course of their disease (Hoover et al, 1996). CMV retinitis remains a major sight-threatening condition in AIDS patients
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