Abstract
AbstractHerpes simplex virus type 1 (HSV‐1) is an endemic virus worldwide that causes ocular disease in a limited but significant number of infected persons. Corneal HSV‐1 infection is clinically classified into herpetic epithelial keratitis (HEK) and herpetic stromal keratitis (HSK). HEK is an acute inflammation and results from viral toxicity of infected corneal epithelial cells. In contrast, HSK is characterized as a chronic immunopathogenic disease in which tissue injury and eventually blindness is due to the complex interplay between cells of the innate and adoptive immune response to viral antigens expressed in the corneal tissue. Studies performed on the experimental HSK mouse model greatly improved our understanding of the pathogenesis of HSK. This talk will recapitulate current insights on the virus‐host interactions involved in the initiation and perpetuation of herpetic keratitis in mice and men.
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